BIOL 464

Population and Quantitative Genetics Schedule

Fall 2008

HOME - SCHEDULE - LABORATORY - BACKGROUND READING

Text: Hedrick, Philip W. 2005. Genetics of Populations. Jones and Bartlett, Sudbury, MA

Note: Unattributed figures and tables in lecture notes are from the Hedrick text.

Day	Date	Topic	Reading
M	18-Aug	Class Introduction and Probability ppt pdf	Ch1, 1-27
W	20-Aug	Lab 1: Probability ppt pdf
F	22-Aug	Measures of Genetic Variation ppt pdf	Ch1, 27-43; Ch2, 97-110
M	25-Aug	Allele Frequencies and Hardy-Weinberg ppt pdf	Ch2, 61-72
W	27-Aug	Lab 2: Hardy-Weinberg Equilibrium ppt pdf
F	29-Aug	Hardy-Weinberg Equilibrium and Genetic Variation ppt pdf	Ch2, 72-97
M	1-Sep	Labor Day-No Class
W	3-Sep	Lab 3: Genetic Variation ppt pdf
F	5-Sep	Linkage Disequilibrium (LD) ppt pdf	Ch 10, 525-541
M	8-Sep	Inbreeding and Kinship ppt pdf	Ch 5, 237-279
W	10-Sep	Lab 4: Linkage Disequilibrium ppt pdf
F	12-Sep	Introduction to Selection ppt pdf	Ch3, 113-146
M	15-Sep	Types of Selection ppt pdf	Ch 5, 279-296; Ch 10, 548-551
W	17-Sep	Lab 6: Inbreeding and Kinship ppt pdf
F	19-Sep	Inbreeding and Selection ppt pdf	Ch3, 147-169
M	22-Sep	Review
W	24-Sep	Exam 1 Answer Key for 2008 Exam Sample Exam from 2007 Review Sheet
F	26-Sep	Genetic Drift ppt pdf	Ch 6, 299-310
M	29-Sept	Drift and Selection ppt pdf	Ch 6, 311-317;
W	1-Oct	Lab 5: Selection ppt pdf
F	3-Oct	Effective Population Size ppt pdf	Ch 6, 318-329
M	6-Oct	Bottlenecks and Founder Effects ppt pdf	Ch 6, 329-349;Ch 10, 541-545
W	8-Oct	Lab 7: Effective Population Size ppt pdf
F	10-Oct	Mutation ppt pdf	Ch 7, 357-370
M	13-Oct	Mutation, Selection, and Drift ppt pdf	Ch 7, 371-405; Ch10 545-548
W	15-Oct	Lab 8: Mutation Rates ppt pdf
F	17-Oct	Introduction to Neutral Theory ppt pdf	Ch 8, 407-428
M	20-Oct	Tests of Neutrality ppt pdf	Ch 8, 429-449
W	22-Oct	Lab 9: Detecting departures from Neutrality ppt pdf
F	24-Oct	Population Structure ppt pdf GST Calculation	Ch 9, 469-499
M	27-Oct	Gene Flow and Selection ppt pdf	Ch 9, 499-522
W	29-Oct	Lab 10: Population Structure ppt pdf
F	31-Oct	Gene Flow and Parentage Analysis ppt pdf	Ch 11, 621-646
M	3-Nov	Review
W	5-Nov	Answer Key for 2008 Exam 2 Exam 2 (see sample exam from 2007) Review Sheet
F	7-Nov	Likelihood and Genetic Identity ppt pdf	Ch 11, 621-650
M	10-Nov	Assignment Tests and Structure ppt pdf	Ch 11, 646-650
W	12-Nov	Lab 11: Individual Identity and Paternity ppt pdf
F	14-Nov	QTL Mapping ppt pdf	Ch 1, 53-58; Ch 11, 650-658
M	17-Nov	Association Genetics ppt pdf	Ch 11, 658-662; Balding 2006
W	19-Nov	Lab 12: Assignment Tests
F	21-Nov	Advanced Association Genetics ppt pdf	McCarthy et al. 2008
M	24-Nov	Thanksgiving Recess
W	26-Nov	Thanksgiving Recess
F	28-Nov	Thanksgiving Recess
M	1-Dec	Molecular Phylogenetics & Phylogeography ppt pdf Tree Thinking Challenge	Ch 11, 597-621
W	3-Dec	Lab 13: Phylogenetic Analysis and Course Evaluations
F	5-Dec	Review
W	10-Dec	Final Exam at 11 am in 3131 LSB (see sample final from 2007)

Balding,D.J. 2006. A tutorial on statistical methods for population association studies. Nature Reviews Genetics 7: 781-791.
McCarthy,M.I., Abecasis,G.R., Cardon,L.R., Goldstein,D.B., Little,J., Ioannidis,J.P.A., and Hirschhorn,J.N. 2008. Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nature Reviews Genetics 9: 356-369.