An exciting development of the research program is the introduction of a new approach to separations based on the coupling of discreet bilayered membranes with electrokinetic chromatography, called membrane mediated electrophoresis [1, 2]. The approach provides a rapid and improved method to estimate lipophilicity, one of four parameters that governs the success of potential drug candidates. In addition, these materials serve as an ideal additive to better facilitate CE separations of proteins and peptides. Recently, membrane mediated electrophoresis was used to investigate the action of membrane pore-formation. This area offers a means to study the poorly understood mechanism of membrane disruption, which affects areas such as discovery of antibacterial agents or gene therapy delivery vehicles.
1. LA Holland, A Leigh, “ Bilayered Phospholipid Micelles and Capillary Electrophoresis: A New Additive for Electrokinetic Chromatography”, Electrophoresis24(17), pp. 2935-2939, 2003.
2. J Mills, LA Holland, “Membrane Mediated Capillary Electrophoresis: Interaction of Cationic Peptides with Bicelles”, Electrophoresis, 25(9), pp. 1237-1242 2004.