Lecture
12: Muscle Physiology - Molecular structure
Sherwood- Chapter 8
Objective:
To understand the structure of actin and myosin and the nature of
crosslinking in the contraction of a muscle fiber.
1.
Sarcomere is the functional unit of skeletal muscle
2. Myofibrils
a. thick filament
and the myosin protein
b. thin filament
and actin, tropomyosin and troponin
3. Role of calcium
a. released from
the sarcoplasmic reticulum
b. binds to troponin
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