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Research Summary
Satheesh
Babu Ravula, Ph. D
418 Medical Center Drive,
Apt A-103
Morgantown, WV 26505, USA
Phone: 304 685 7429
(Mobile), e-mail:
Satheeshbabur@hotmail.com
PERSONAL
EXPERIENCE
| 2002-Present: |
Postdoctoral Research Associate
Department of Chemistry, West Virginia University, Morgantown, WV 26505,
USA.
Research Advisor: Prof. George A O’Doherty. |
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Duties: |
Ø
Development of
methodologies and asymmetric synthesis of biologically active compounds.
Ø
Training graduate
and undergraduate students with their daily research problems.
Ø
Business Manager for
Prof. O’Doherty group (Purchasing and chemical inventory management).
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| Projects: |
1.1.Development of Diastereoselective and stereospecific Palladium-Catalyzed
Glycosylation Reaction.
2. De Novo Synthesis of Oligosaccharides: linear and branched
oligosaccharides.
3. Towards Asymmetric Total Synthesis of Mannopeptimycin.
4. De Novo Synthesis of macrolide antibiotic glycosides Methymycin and
Erythromycin analogues.
5. De Novo Synthesis of Trehalose Analogues.
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| 1996-2002:
|
Junior and Senior Research Fellow
Indian Institute of
Chemical Technology (IICT), Hyderabad, AP 500 007, India.
Research
Advisor: Dr. J. S. Yadav.
|
|
Duties: |
1. Asymmetric synthesis of biologically active
compounds and development of methodologies.
2. Purchase coordinator for Dr. Yadav’s research group.
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| Projects: |
1. Stereoselective total
synthesis of antimalarial natural product (+) Artemisinin.
2. Synthesis of spirolactones using Grubb’s ring closing metathesis.
3. Synthetic studies of Pondaplin: Total synthesis of Pondaplin analogues.
4. Developed novel method for the deprotection of MEM ethers.
5. Developed a novel method for the syntheses of halohydrins and
azidohydrins.
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EDUCATION |
Ø
Ph.D., Organic Chemistry, University of Pune, Pune, India, 2002
Thesis Title: “Stereoselective Total Synthesis of (+)-Artemisinin and
Development of Novel Synthetic Methodologies”
Research Advisor Dr. J. S. Yadav, Director, IICT, Hyderabad, India.
Ø
M.S., Chemistry, University of Pune, Pune, India, 1996
Ø
B.S., Chemistry and Biology, Kakatiya University, Warangal, India, 1992
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HIGHLIGHTS |
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Over seven years of research experience in synthetic organic chemistry.
Ø
Strong background in asymmetric synthesis and total synthesis of natural
products.
Ø
Experience in writing scientific manuscripts.
Ø
Training graduate and undergraduate students with their daily research
problems.
Ø
Extensively trained in multi-step organic synthesis utilizing modern
structural elucidation techniques.
Ø
Operational experience of modern laboratory instruments: NMR, IR, HPLC, GC
and Polarimeter.
Ø
Demonstrated success in technical proficiency, scientific creativity,
collaboration with others and independent problem solving skills.
Ø
2.5 years as Prof. O’Doherty group business manager
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US permanent resident with valid work authorization.
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AWARDS |
Ø Graduate Research Fellowship (1994-1996)
Ø
Junior and Senior Research Fellowship (1996-2002) |
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MEMBERSHIPS |
Ø
Member of American Chemical Society (ACS)
Ø
Member of International Union of Pure and Applied Chemistry (IUPAC) |
PUBLICATIONS AND PATENT
18. “Synthetic Studies Towards Mannopeptimycins: De-Novo
Synthesis of Tyrosine Disaccharide Fragment” Ravula Satheesh Babu, Sanjeeva R.
Guppi and George A. O’Doherty Manuscript ready for submission.
17. “De Novo Synthesis of Oligosaccharides Using A Palladium Catalyzed
Glycosylation Reaction” Ravula Satheesh Babu, Maoquan Zhou and George A.
O’Doherty J. Am. Chem. Soc., 2004, 126, 3428-3429.
16. “Palladium Catalyzed Glycosylation Reaction: De-Novo Synthesis of
Trehalose Analogues” Ravula Satheesh Babu and George A. O’Doherty J. Carbohydr.
Res., In Press.
15. “A Palladium-Catalyzed Glycosylation Reaction: The de Novo Synthesis of
Natural and Unnatural Glycosides” Ravula Satheesh Babu and George A.
O’Doherty J. Am. Chem. Soc., 2003, 125, 12406-12407.
14. “Cerium (III) Chloride Hepta Hydrate” Ravula Satheesh Babu Synlett., 2002,
11, 1935-1936.
13. “Total Synthesis of (+) Artemisinin” J. S. Yadav, R. Satheesh Babu and G.
Sabitha, Arkivoc., 2003, 3, 125-139.
12. “Stereoselective Total Synthesis of (+) Artemisinin” J. S. Yadav, R.
Satheesh Babu and G. Sabitha Tetrahedron Lett., 2003, 44, 387-389.
11. “Ring Opening of Epoxides and Aziridines with Sodium Azide using Oxone® in
Aqueous Acetonitrile: A Highly Regioselective Azidolysis Reaction” G. Sabitha,
R. Satheesh Babu, M. S. K. Reddy, J. S. Yadav Synthesis, 2002, 2254-2258.
10. “Cerium(III) Chloride Promoted Highly Regioselective Ring Opening of
Epoxides and Aziridines Using NaN3 in Acetonitrile: A Facile Synthesis of
1,2-Azidoalcohols and 1,2-Azidoamines” G. Sabitha, R. Satheesh Babu, M.
Rajkumar and J. S. Yadav Org. Lett., 2002, 4, 343-345.
9. “The Synthesis of Spirolactones Using Indium-Mediated Allylation of Cyclic
Anhydrides and Ring-Closing Olefin Metathesis” G. Sabitha, Ch. S. Reddy, R.
Satheesh Babu and J. S. Yadav Synlett, 2001, 1787-1789.
8. “Highly Regioselective Ring Opening of Epoxides and Aziridines Using Cerium
(III) Chloride” G. Sabitha, R. Satheesh Babu, M. Rajkumar, Ch. S. Reddy and J.
S. Yadav Tetrahedron Lett., 2001, 42, 3955-3958.
7. “A Highly Efficient, Mild and Selective Cleavage of b-Methoxyethoxymethyl (MEM)
Ethers by Cerium (III) Chloride in Acetonitrile” G. Sabitha, R. Satheesh Babu,
M. Rajkumar, R. Srividya and J. S. Yadav, Org. Lett., 2001, 3, 1149-1151.
6. “A Novel, Efficient, and Selective Cleavage of Alkyl tert-Butyldimethyl
Silyl Ethers Using BiCl3/NaI System” G. Sabitha, R. Satheesh Babu, E. V.
Reddy, R. Srividya and J. S. Yadav Adv. Synth. Catal., 2001, 343, 169-170.
5. “A Novel, Efficient, Selective Cleavage of Acetals and Ketals Using Bismuth
(III) Chloride” G. Sabitha, R. Satheesh Babu, E. V. Reddy, and J. S. Yadav
Chem. Lett., 2000, 9, 1074-1075.
4. “Microwave Assisted Friedlander Condensation Catalysed by Clay” G. Sabitha,
R. Satheesh Babu, B. V. S. Reddy, and J. S. Yadav Synth. Commun., 1999, 29,
24, 4403-4408.
3. “LiCl Catalysed Knovenagel Condensation: Comparitive Study of Conventional
Method vs Microwave Irradiation” G. Sabitha, B. V. S. Reddy, R. Satheesh Babu,
and J. S. Yadav Chem. Lett., 1999, 8, 773-774.
2. “One Pot synthesis of 4-(2’-Hydroxybenzoyl) Pyrazoles from 3-Formyl
Chromones under Microwave Irradiation in Solvent Free Conditions” G. Sabitha,
R. Satheesh Babu, and J. S. Yadav Synth. Commun., 1998, 28, 24, 4751-4756.
1. “An Imporoved Process for the Preparation of Esters from Carboxylic Acids
Using Lewis Acid Catalysts” G. Sabitha, R. Satheesh Babu, and J. S. Yadav
Indian Patent (CSIR), 3561/DEL/98 Nov. 27).
PRESENTATIONS AT
SYMPOSIA
1. Oral Presentation on “Synthetic
Studies of Mannopeptimycin: De Novo Synthesis of Disaccharide Fragment for
Model Study” at 228th National ACS Meet at Philadelphia (August 22-26, 2004).
2. Two Poster presentations at 228th National ACS Meet at Philadelphia (August
22-26, 2004).
3. Oral Presentation on “De-Novo Synthesis of Oligosaccharides, Palladium and
Osmium Asymmetric Catalysis” at 227th National ACS Meet at California (March
28th to April 1st 2004).
4. Poster Presentation at 35th Central Regional ACS Meet at Pittsburgh
(October 19-22, 2003).
5. Poster Presentation at 38th National Organic Symposium at Indiana
University (June 8-12, 2002).
6. Participated in 1st and 2nd National Symposium in Chemistry at IISc and
IICT at India.
REFERENCES
|
Prof. George A. O’Doherty
Associate Professor
217 Clark Hall of Chemistry
284 Prospect Street
Morgantown, WV 26505
Phone: 304 293 3435 Ext. 6444
George.Odoherty@mail.wvu.edu
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Dr. J. S. Yadav
Director
Indian Institute of Chemical Technology (IICT),
Uppal Road
Hyderabad, AP 500 007
Phone: +91 40
27193030
yadav@iict.res.in
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Prof. Kung K. Wang
Professor
217 Clark Hall of Chemistry
284 Prospect Street
Morgantown, WV 26505
Phone: 304 293 3435 Ext. 6441
kwang@wvu.edu
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